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glutathione s-transferase mediated reaction transferases as mediators of signaling pathways involved in cell proliferation and cell death Figure 2 from The Role
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Most eukaryotic cells rely on oxygen for respiratory energy production, while in hypoxia, cellular metabolism is forced to be reprogrammed, which manifests as a boost in anaerobic glycolysis and suppression of mitochondrial activity [3]

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Importantly, luteolin was also able to increase the dopamine level by increasing the activity of tyrosine hydroxylase (TH), which is a key enzyme responsible for generating dopamine [66]
