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If target IOP is not achieved in a compliant patient, substitution or addition of newer medications can be considered. Real- world studies have shown both latanoprostene bunod and netarsudil to provide additional IOP reductions in patients already taking three or more medications

doi: 10.1016/j.heliyon.2019.e01791

Benedetti MS, et al

Neuroinflammation 14, 63

doi: 10.1093/jn/121.7.1054 144 BuckmasterPSHollidayTABaiSCRogersQR

Human evidence: Weak and observational
