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Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4

Although it is not well known whether loss of intestinal barrier per se in IBD patients is causal to bone loss in these patients (see chapter on IBD and bone for further details), our lab has shown that intestinal inflammation without weight loss in an IBD model can lead to significant bone loss suggesting a link [85]

25 ROS links ER stress with oxidative stress

Elevated superoxide generated from dysfunctional mitochondria promotes the formation of excessive H 2 O 2 , the substrate for MPO-mediated hypochlorous acid synthesis and the generation of the inflammatory biomarker, 3-CT

Statistical analysis of metabolomic data Standard statistical analyses were performed in Array Studio on log-transformed data

All animal experiments were carried out upon approval of the Institutional Animal Care and Use Committee of Harbin Institute of Technology University