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Pathway enrichment analysis revealed that these genes were enriched in 170 signaling pathways, and the top 20 signaling pathways most closely related to AD were the following (Supplementary Table 2): AD-related pathways include neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, calcium signaling pathway, cAMP signaling pathway, MAPK signaling pathway, Ras signaling pathway, serotonergic synapse, pathways of neurodegeneration multiple diseases, Rap1 signaling pathway, AD and AGE-RAGE signaling pathway in diabetic complications

doi:10.3389/fendo.2019.00155 Bucheit JD, Pamulapati LG, Carter N, Malloy K, Dixon DL, Caldas LM

The results indicate a protective role of GSTP1 by enhancing GSH-conjugation, which might lead to a reduced protein modification, and suggest a second protective role by interfering with the unfolded protein response, thereby preventing apoptosis

Newman et al [] also reported a case of a G6PD deficiency patient who showed no improvement after VitE supplementation, although it protects the membrane of RBCs from lipid peroxidation

In terms of lipogenesis, the phosphorylation of INSIG1 at S207 disrupts its ability to inhibit SREBP, a key regulator of adipogenesis, thereby sustaining elevated lipogenesis in tumor cells [29]

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