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The peripheral blood shows severe macrocytic anemia, sometimes accompanied by neutropenia andor thrombocytopenia

The hematologic consequences of diminished synthesis of one globin chain stem not only from hemoglobin deficiency but also from a relative excess of the other globin chain, particularly in -thalassemia (described later)

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Although increasingly veterinary surgeons have the ability to measure ionised calcium inhouse, the astute clinician may suspect ionised hypocalcaemia by identification of a prolonged Q-T segment on an echocardiogram (ECG)

However, excessive NRF2 signaling suppresses expression of critical microbicidal effector molecules in bone marrow-derived macrophages (BMMs), impairing mycobacterial clearance ( To determine whether Rv0801 influences the KEAP1-NRF2 axis, we first analyzed Nrf2 transcriptional activity in THP-1 macrophages infected with Rv0801 recombinant strains