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Immune system evasion as hallmark of melanoma progression: the role of dendritic cells

8.1 Gene modification of MSCs Genetic modification of mesenchymal stem cells (MSCs) using viral or non-viral vectors can induce the overexpression of functional proteins and soluble factors, thereby enhancing stemness, differentiation, migration and homing capabilities, immunomodulation, and other repair-related functions ( in vitro and in vivo ), and improving their resistance to harsh microenvironments and apoptosis

A vial reconstituted with careful technique and stored properly retains measurably higher activity at day 28 than one mixed carelessly and subjected to temperature fluctuations, even if both spent the same amount of time in the same refrigerator

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