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OXPHOS protein expression was significantly upregulated in the moderate-mutant group, particularly for complex II, compared to the low-mutant group (Fig

Caffeine belongs to the xanthine group and acts as a nonspecific antagonist of adenosine receptors, mainly A 1 and A 2A [12]

Use morning, evening, or both

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The abrupt changes in the light dark cycle and consequent desynchrony experienced by shift workers and time zone travelers are now known to be associated with increased risk of accidents, sleep deficits, lowered alertness and performance, gut problems, lowered fertility, perhaps psychiatric problems, and increased risk of major disease such as cancer, diabetes, metabolic syndrome and heart disease (67, 97)