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Type 3 (mixed) includes the polyclonal immunoglobulins of all isotypes linked to essential cryoglobulinemia, Sjogrens syndrome, SLE, viral infections (HBV, HCV, CMV, EBV, and HIV), endocarditis, other bacterial infections, and biliary cirrhosis [1178]
Bardou, P., Mariette, J., Escudi, F., Djemiel, C
New Provence, N.J
Activated TGF-RI then recruits and phosphorylates the downstream signaling molecules SMAD family members SMAD2 and/or SMAD3, which subsequently combine with SMAD4 to form a heterotrimeric complex
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