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However, some sickled RBCs are irreversibly changed, indicating that the membrane cytoskeleton has been damaged

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Rios de la Rosa JM, Pingrajai P, Pelliccia M, et al

This is particularly important for generating GSH, since neuronal cells have a lower synthesis and, consequently, GSH concentrations, compared to astrocytes (Makar et al., 1994

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This information can be valuable for your healthcare provider in determining the best course of action