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1 study involving 16 patients who underwent solid organ transplant and were receiving prophylactic dapsone reported that methemoglobinemia presented at a median 48 (range 7809) days after treatment began

It has not been tested for use in diagnostics or drug development, nor is it suitable for administration to humans or animals

Requires good side-effect management

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This review reinforces contemporary practice trends toward ultrasound-guided, indication-specific selection of sciatic blocks rather than a one-size-fits-all approach.