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This milieu causes substantial metabolic and functional alterations in tumor-infiltrating T cells, facilitating the escape of liver cancer cells from immune surveillance [18]

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It also promotes angiogenesis via VEGF upregulation and wound contraction through actin remodeling

Shea B, Swinden MV, Tanjong Ghogomu E, Ortiz Z, Katchamart W, Rader T, Bombardier C, Wells GA, Tugwell P (2013) Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis

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The AS01 B adjuvant suspension is composed of 3- O -desacyl-4'-monophosphoryl lipid A (MPL) from Salmonella (Minnesota strain) and a saponin molecule (QS-21) purified from Quillaja saponaria (soap bark tree) extract, combined in a liposomal formulation consisting of dioleoyl phosphatidylcholine (DOPC) and cholesterol in phosphate-buffered saline solution
