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Isatuximab binds to a specific epitope that partially encompasses, but does not block access to or alter the configuration of the CD38 ectoenzyme catalytic site [11, 20]
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Institutional research settings that track NAD+ levels and methylnicotinamide excretion often find individual dose-response variability of 3040%, meaning the 'right' dose for one subject may be subtherapeutic or excessive for another
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