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This is conferred by a targeted amino acid substitution at the 8th position, replacing alanine with glutamic acid, a modification also found in exenatide-based GLP-1 therapies

PMC 3441227

Pickart, L., Vasquez-Soltero, J., Pickart, F., & Majnarich, J

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These can include injection site irritation, headache, flushing or warmth, fatigue, mild gastrointestinal discomfort such as nausea, dizziness, or changes in appetite

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