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In another six-month, randomized, double-blind, placebo-controlled study of subjects with mild-to-moderate AD, curcumin failed to improve cognitive test scores and to reduce blood and cerebrospinal fluid (CSF) concentrations of -amyloid peptide, CSF concentrations of total and phosphorylated Tau protein, and CSF concentrations of F 2 -isoprostanes (98)

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[] While these metals do have essential biological functions, they are however needed only in miniscule amounts, and should an excessive intake of these metals occur or accumulate, their presence can result in cellular and tissue damage, which could result in disease and disorders among humans