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[DOI] [PubMed] [Google Scholar] 16.Burford N., Eelman M.D., Groom K

This protection is crucial because ROS are not only engaged in signal transduction, but also can oxidize lipids, inhibit enzymes, inactivate biomolecules, and damage proteins, RNA, and DNA, causing a critical level of cell damage

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The consistent clinical failure of agents targeting a single mode of cell death provides compelling clinical validation for the mechanistic principle outlined in Section 2.4.2: MIRI triggers an interconnected web of cell death programs, suggesting future strategies may need to be multi-modal or target more upstream events

Sub-ppm level high energy resolution fluorescence detected X-ray absorption spectroscopy of selenium in articular cartilage

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