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Effect of different chronic intermittent stressors and acetyl-L-carnitine on hypothalamic beta-endorphin and GnRH and on plasma testosterone levels in male rats Neuroendocrinology 1993

The functions of carnitine/acylcarnitine in signaling may differ according to the cell type and physiological state

This inflammation reaches the systemic level and, subsequently, the central nervous system (CNS), which can lead to oxidative stress and mitochondrial dysfunction, resulting in brain damage

ALCAR and acetylcholine A number of studies have shown that ALCAR administration maintains and/or increases acetylcholine levels in brain [101, 158161]

Several clinical studies have evaluated the impact of L-carnitine (often combined with Acetyl-L-carnitine) on sperm quality in men facing fertility disorders

It is important to explore its effects on specific cells of the male reproductive system, such as Sertoli and Leydig cells, and to investigate the signaling pathways involved in its action