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If homocysteine is high, the many factors listed in Table 3 need to be addressed as well as supplementation with the activated forms of B 6, folate (not folic acid) and B 12

Oxidative stress implications in the affective disorders: main biomarkers, animal models relevance, genetic perspectives, and antioxidant approaches

Bicknell B, Liebert A, Borody T, Herkes G, McLachlan C, Kiat H

Accumulating evidence suggests that many environmental and dietary factors, especially chronic ethanol exposure, aggravate the risk of this disease

For higher doses, the 1ml reconstitution may be more practical

If you've exhausted other troubleshooting and still have issues, source quality deserves investigation