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Modalities such as Platelet-Rich Plasma (PRP) therapy, targeted nutritional interventions, and approved medications can provide similar benefits

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LRRK2 mutations possess a complicated relationship with mitophagy, as the same G2019S mutations have demonstrated various mechanisms of mitophagy alterations, from increasing mitophagy through histone deacetylase activation 136 , or in contradiction, to decreasing mitophagy 162 probably through compromised Miro removal 7 , sirtuin activity 163 or aberrant RAB10 phosphorylation 164

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Shots may help reduce or prevent this damage