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This approach can achieve the goal of increasing efficiency and reducing toxicity, highlighting the advantages of combination therapy

10.1093/toxsci/kfae159 23 CaoX.CoyleJ

A method for detecting abasic sites in living cells: age-dependent changes in base excision repair

We also observed activation of other stress responses in individual tissues, such as the integrated stress response (ISR) (Atf4, Atf5) in liver and muscle, oxidative stress (Nrf2, Hmox1) in muscle, and mitochondrial biogenesis (Pgc1a) and the mitokine Gdf15 in eWAT (Fig 1G)

At present, there is no standard clinical treatment for OXA-induced ALI