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Because street MDMA varies so widely in composition, users might experience short-term positive effects in one instance but suffer adverse reactions in another, especially if other drugs or fillers are present

DSIP primarily functions by modulating the central nervous system, particularly through interactions with GABA and NMDA receptors

Trang A, Khandhar PB (2025) Physiology, acetylcholinesterase

Such inflammatory molecules induce cell apoptosis, senescence and autophagy and upregulate the synthesis of MMPs (1, 3, 7, 9 and 13) and ADAMTS (1, 4, 5, 9 and 15) through NPCs, thus leading to ECMs catabolism (Risbud and Shapiro, 2014)