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Age-specific changes in brain GSH levels were assessed cross-sectionally using MRS in the living brain and/or biochemical assays in autopsy tissue in 10 unique ROIs, of which six (occipital, precuneal, posterior cingulate, anterior cingulate (medial pregenual), medial frontal and prefrontal dorsolateral regions) had been investigated by reproducibility studies with reliable GSH measures demonstrated

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[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Tao S., Rojo de la Vega M., Chapman E., Ooi A., Zhang D.D

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This could be linked to the fact that SERCA inhibition leads to great amounts of Ca 2+ released from the ER which may overwhelm redox-mediated changes of CRAC ( 2+ mobilization, while STIM1 could be recruited by strong ER Ca 2+ depletion ( 2 Y receptors activation and oxidative stress

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