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Under current FDA guidance, a 503A pharmacy can compound a GLP-1 medication for a specific patient only when the prescriber documents a "significant difference" - a genuine clinical reason why the compounded formulation serves that patient's specific medical need in a way the commercially available FDA-approved product cannot

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However, the limited follow-up duration of 6 months raised concerns about potential reverse causality, as undetected suicidal ideation and medical conditions might have influenced the choice of particular anti-obesity or anti-diabetic drugs

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