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In UVA- and UVB-irradiated keratinocytes, TrxR and CAT activity increased by about 50% and twofold, respectively, and for fibroblasts TrxR and CAT activity increased by 55% and threefold following UVA radiation, and twofold and around 30% following UVB radiation

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In fact, geraniin, at a dose of 20 mg/kg injected intraperitoneally, was recently shown to ameliorate cisplatin-induced nephrotoxicity in mice by inhibiting OS and inflammatory response ( Geraniin has also been reported to exhibit neuroprotection in an in vitro study

While methodological variability exists, the convergence of cellular, enzymatic, and histological endpoints strengthens the evidence supporting biologically meaningful redox modulation by GHK-Cu

In an indirect way, allogenic proteins are degraded by recipient APCs, and autologous MHCs present the allogenic peptides derived from them

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