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1 Moreover, the high failure rate of clinical trials makes it difficult to effectively validate hypotheses, possibly attributed to the coexistence of multiple theories (which will be detailed in subsequent sections)

The metabolism and distribution of these compounds are modulated by complex processes, including the role of the gut microbiota, which can modify the chemical structure of antioxidants, thereby affecting their activity and bioavailability

Expression and function of EZH2 in synovial fibroblasts: epigenetic repression of the wnt inhibitor SFRP1 in rheumatoid arthritis

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However, IL-6 is often overlooked as also an anti-inflammatory cytokine, as IL-6 also dampens the inflammatory cascade by signaling for the release of various anti-inflammatory cytokines such as interleukin-10 (IL-10) [52]