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However, given that NF-B is involved in diverse biological processes related to inflammatory response, cell adhesion, growth control, and protection against apoptosis (87), its inhibition could lead to multiple unwanted side effects

It should also be noted that there was a protocol deviation in the renal impairment study whereby participants were assigned to renal function groups using an eGFR value expressed in mL/min/1.73 m 2 instead of mL/min

Potential Benefits & Side Effects Observations from limited and dated preclinical and clinical literature

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Assessing treatment outcomes in multiple sclerosis trials and in the clinical setting