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ArfGAP1 also contains a similar ALPS1 motif (residues 199-234), with both ALPS motifs localized to the non-catalytic C-terminal portion of ArfGAP1 relative to the GAP catalytic domain localized within the first 136 residues [44, 45]

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Thus, its modulation can be used as a valuable strategy to develop therapies against diseases related to the brain and muscle, such as psychiatric disorders and neurodegenerative and muscular diseases

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Nature 458 , 11311135 (2009)