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however, IgM as well as IgA along with Complement, have also been shown to be capable of ADE 71,72

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Estrogens and estrogen quinone metabolites can have the same damaging effects as ROS, alkylate, or damage the integrity of DNA and proteins, and also bind to estrogen receptors and activate estrogen response elements, which leads to increased levels of ROS [275]

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That is why patients with macular degeneration may still move around a room but struggle to read a label, recognize a face, or see small details

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