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In general, a number of animal AD model studies suggest that white matter pathology emerges prior to appearance of cortical plaques and tangles [29, 30, 40]

doi: 10.1016/j.redox.2025.103566 217 KwonJHLeeJKimJKirchnerVAJoYHMiuraTet al

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Homocysteine Explained As a sulfur-containing non-essential amino acid, homocysteine acts as an intermediate in two main pathways, the methylation cycle, and the transsulfuration pathway