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In many cancers associated with mutations in genes encoding electron transport chain proteins there is increased ROS production that is associated with resistance to apoptosis

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Therefore, HIF-1 likely exerts a suppressive effect on ferroptosis in affected cells by upregulating antioxidant systems, exerting a protective role similar to its anti-apoptotic effects in osteoblasts

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The main mechanism responsible for the observed permanent distal sensory loss is associated with the death of sensory neurons (i.e., nerve cell necrosis) due to the binding of oxaliplatin to mitochondrial DNA [36]