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J Clin Endocrinol Metab (2021) 106(3):91221

The innovations in drug design and formulation that we just covered, including dual and triple agonists or conjugates with other hormonal pathways, are helping driving this expansion by delivering greater weight loss and metabolic benefits while reducing side effects through synergistic mechanisms

These drugs also simultaneously decrease levels of an enzyme called DPP-4, which inactivates GLP-1

GIP analogues and the treatment of obesity-diabetes

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p = 0.05) between the treatment and placebo groups was observed in MDS-UPDRS Part II, with high inter-study heterogeneity (I 2 = 83%, p = 0.0001)