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Ferroptosis is associated with pathological cell death associated with mammalian degenerative diseases (e.g., Alzheimer's disease, Huntington's chorea, and Parkinson's syndrome), tumors, stroke, cerebral hemorrhage, traumatic brain injury, local ischemia-reperfusion injury, and renal failure

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10.1016/j.pbb.2011.01.011 163 NagashayanaN.SankarankuttyP.NampoothiriM.MohanP.MohanakumarK

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These distinguished effects may be attributed to the TME modulation capacity of H-MnO 2 -based nano-platform and the subsequently enhanced chemo-PDT treatment to induce the release of tumor-associated antigens 49, 50 , which would activate dendritic cells and then the recruitment of effector T cells into tumors