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With a similar oxygen affinity to myoglobin ( P 5 0 = 110 mmHg), in vivo experiments indicate its role in protecting the brain and nervous system from hypoxia and oxidative stress 68

Overview of the Mechanisms of Oxidative Stress: Impact in Inflammation of the Airway Diseases

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As a lipophilic antioxidant, ubiquinol directly neutralizes lipid radicals, establishing a GPX4-independent defense mechanism against ferroptosis ( 3.1.3.3 The Nrf2/ARE pathway Nrf2 is a master regulator of cell defense systems involved in detoxification, antioxidant defense, and resolving inflammation and fibrosis (Murakami et al., 2023)

Notably, we delve into the critical challenges and considerations currently facing lymphatic nanomedicines, and futher propose effective strategies to address these issues

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