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doi: 10.1104/pp.113.222703 36 Diaz-VivancosP.FaizeM.Barba-EspinG.FaizeL.PetriC.HernndezJ

This can lead to irreversible neurological symptoms

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The ingestion of a high-calorie diet or the consumption of substantial amounts of alcohol has been demonstrated to promote DNL through the activation of two transcription factors: carbohydrate response element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c)

Contact Information Takyiah Stevenson, PharmD Center for Drug Evaluation and Research Food and Drug Administration 10903 New Hampshire Avenue WO31-2417 Silver Spring, MD 20993-0002 Phone: 240-402-2507 Email: [email protected] FDA Advisory Committee Information Line: 301-796-8220 Please call the Information Line for up-to-date information on this meeting

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