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371 It was shown that the core promoter regions, contributing to the regulation of ZIP1 expression, are modulated by SP1 as well as CREB

ROS and necroptosis can form a necroptotic loop: ROS stabilizes receptor interacting protein kinase 3 (RIP3) to promote the necrosome formation, while RIP3 enhances ROS generation through metabolic signaling [152]

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REPEATED IMMUNE ACTIVATION LEADS TO MICROGLIAL ACTIVATION, EXCESS GLUTAMATE, AND NEUROPATHOLOGICAL CHANGES IN THE NEUROPIL THAT CAN BE BLOCKED BY GLUTAMATE RECEPTOR BLOCKERS Prolonged and repeated systemic immune activation appears to be central to ASD etiopathology