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What it does: Methionine donates methyl groups for the synthesis of S-adenosyl-methionine (SAMe), which drives phosphatidylcholine production and helps assemble very-low-density lipoproteins (VLDLs)

Mitophagy defects have been found in neurodegenerative diseases such as Hungtingtons disease, Alzheimers disease and Parkinsons disease (Schapira and Gegg, 2011

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Jun 2014;28(6):766-72

Like POLG mutations, other genetic abnormalities that impair mtDNA replication, including C10orf2 , DGUOK , MPV17 , PEO1 , and SUCLG1 , are part of the hepatocerebral mitochondrial DNA depletion syndromes, which are syndromes that include prominent liver failure (70, 75, 76)

doi: 10.1186/s12967-020-02356-2 22 CorbittMEaton-FitchNStainesDCabanasHMarshall-GradisnikS