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Early degradation is invisible the solution remains clear and colorless while peptide bonds cleave at the molecular level

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Lancet 359:20532058 Belch J, Hiatt WR, Baumgartner I, Driver IV, Nikol S, Norgren L, Van Belle E, Committees T, Investigators (2011) Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia

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The usual advice is to start with the lowest dose available

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FISLE-412 has shown effectiveness in vitro and in vivo

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