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Clinical translation remains uncertain, as illustrated by the neutral outcome of a trial with an oral p38 inhibitor in non-ST-elevation myocardial infarction [167]

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doi: 10.1371/journal.pone.0048924

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Solute Carrier Family 7 Member 11 (SLC7A11, xCT), a cystine transporter, is often highly expressed in tumor cells, which not only participates in the synthesis of glutathione (GSH), but also plays an indispensable role in the inhibition of oxidative stress-induced ferroptosis

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Following the matrix degradation and loss of intercellular contacts, NE appears to participate in the inflammatory features of eczematous diseases resulting in spongiosis and desquamation

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