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However, functional contributions of GPX3 to autophagy-related ferroptosis have not been fully understood

By neutralizing the reactive oxygen species that act as triggers for mast cell degranulation, glutathione helps stabilize these hyperactive immune cells, reducing the systemic flood of histamine and inflammatory cytokines

In the brain, a bidirectional relationship between iron overload and neuroinflammation creates a vicious cycle that could eventually boil down to ferroptosis-mediated neuronal death

The reduced form of GSH acts as a main intracellular antioxidative buffer with multifaceted action against tissue oxidative stressors [5]

To test this possibility, we co-immunostained glucagon and the Golgi marker GM130 in TC1-6 cells

doi: 10.1016/j.exer.2006.07.022 113 TsentalovichYPSnytnikovaOASagdeevRZ