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Overall, the currently available clinical studies/trials support the use of Se supplementation to improve male infertility, although high heterogeneity, insufficient numbers of participants, and lack of RCTs to control for possible confounding do not permit general recommendations to be made

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Funding Statement This research was funded by Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (grant number CNPq n 402270/2021-5) and Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES), Brasil (Finance Code 001)