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A one-year study in postmenopausal women with weak bones found that taking a supplement with manganese and copper, as well as vitamin D, calcium and other nutrients, improved bone mass ( Additional research has shown that manganese and copper in combination with calcium and zinc may prevent bone loss in healthy older women ( Summary Research in both animals and humans suggests that adequate levels of manganese and copper two nutrients that are abundant in fava beans may promote bone strength

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Freeny PC, Hauptmann E, Althaus SJ, et al

Cardamonin suppresses melanogenesis by inhibition of Wnt/beta-catenin signaling

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The enlargement could be due to insufficient GTP levels needed to complete autophagy