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Tingling or numbness (carpal tunnel-like symptoms) As IGF-1 rises, fluid retention in connective tissues can cause transient nerve compression, similar to mild carpal tunnel syndrome

Marlin, MD , and Dr

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Macrophages, including microglia, tend to migrate toward regions of stiffer and denser mechanical gradients, a process known as tropism (Blaschke et al., 2020)

Functioning as a neuromodulator, DSIP influences the activity of GABAergic, glutamatergic, and opioid systems, which are integral to sleep, mood regulation, and pain perception ( 2, 6, 7 )