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These anti-inflammatory or anti-cancer active ingredients are main components of KO, and their beneficial mechanisms of skin health can be used as a reference for further research on KO's skin protection

During strong autoimmune responses or central nervous system infections, immune cells like leukocytes, monocytes, and macrophages can cross the BBB using paracellular and transcellular routes[187]

Dysfunction of lipid metabolism can suppress peroxisome-derived membrane phospholipid synthesis, leading to neutrophil apoptosis without affecting neutrophil energy metabolism or differentiation (122)

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For selectivity studies, recombinant GSTO1 (1 M), PDI (1 M), BSA (1 M) or GRP78 (1 M) in reaction buffer were incubated with C1-27 or DMSO for 30 min at 37 C, followed by incubation with CMFDA (500 nM), BODIPY- C1-27A (1 M) or DMSO for 30 min