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Patients were categorized into high-risk and low-risk groups according to the signature, with the high-risk group showing significantly worse overall survival (5-year survival: 38.9% compared to 79.8% in the low-risk group)

The glutathionylation site was identified as Cys-72 and this residue could be modified either by GSSG or S -nitrosoglutathione

DA synthesis is a process that results in massive production of ROS (Lotharius and Brundin 2002

Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice

Removal by natural or artificial mutation of this arginine residue completely abolishes glutamine feedback inhibition in these GS homologue similar to the Bacillus subtilis GS homologue

Behavioral assessments at baseline were successfully performed in 24 subjects within placebo the group and 20 subjects within the CRWP group (Table 2)