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Overexpression of SIRT3 in HSCs not only ameliorates aging-associated HSC decline, but also improves the function of distant tissues, including attenuation of age-related declines in cognition and motility, via myeloid cells with modulated inflammatory programs

TNF tumor necrosis factor-alpha

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10: 7195-206 Durch Annahme einer - durch das parabelfrmige Strmungsprofil des Blutplasmas vorgegebenen - "Pfeilspitzenform" in engen Gefen knnen rote Blutkrperchen (die im Ruhezustand einen Durchmesser von etwa 7 m haben - Diskozyten, unten) durch enge Kapillaren - bis zu 3 m Durchmesser - strmen (oben)

In TC, there is a universal PKM2 upregulation [68], involving circNRIP1 activated by alkB homolog 5 (ALKBH5) decrease [69], AMP-activated protein kinase (AMPK) [70], downregulated micro RNAs (miRNAs) such as miR-148a and miR-326 [71], BRAF mutation [72], as well as overexpression of phosphoribosyl pyrophosphate amidotransferase (PPAT) [73] and SIRT6 [48]