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1 Introduction Ovarian cancer (OC) is the most lethal gynecological neoplasm due to its high mortality ( Immune cells are a cluster of different cells that have differentiated from bone marrow hematopoietic stem cells ( Immunotherapy is the next generation of treatment that is rapidly developing after traditional treatments such as surgery, radiotherapy, and chemotherapy ( + tumor-infiltrating T cells with a high affinity for antigens ( 2 Overview of TIME metabolism in ovarian cancer Tumors have a complicated metabolic pattern that is a highly adaptable response to hypoxia and nutritional deficiency ( 2.1 Metabolism of ovarian cancer cells Ovarian cancer cells have a heterogeneous metabolism, which means they are able to modify their metabolic patterns in response to their microenvironment ( Figure 1A )

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supervised and revised the final version of the manuscript