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Oxidative stress throws a wide net in terms of the types of macromolecules and organelles it threatens including proteins, fats, DNA, and even mitochondria

Synthesis, SAR study, and biological evaluation of novel 2,3-dihydro-1H-imidazo[1,2-a]benzimidazole derivatives as phosphodiesterase 10A inhibitors

doi: 10.2174/1381612829666230201121353

Pain modulation is one of the major functions of KORs in the CNS, particularly through supraspinal analgesia [61]

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The main targets of oxidative stress damage are DNA, lipids and proteins ( Figure 1 )