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10.1111/j.0954-6820.1978.tb08402.x [DOI] [PubMed] 50.Berlin H, Berlin R, Brante G (1968) Oral treatment of pernicious anemia with high doses of vitamin B12 without intrinsic factor

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doi: 10.1111/j.1365-2133.2008.08462.x

However, individuals with a deficiency may require higher doses for treatment

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[115] This functionality is lost in vitamin B 12 deficiency, resulting in an increased homocysteine level and the trapping of folate as 5-methyl-tetrahydrofolate, from which THF (the active form of folate) cannot be recovered