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These factors induce oxidative stress, endoplasmic reticulum (ER) stress, or DAMPs release, resulting in inflammation, immune dysregulation, and melanocyte destruction ( NLRP1 and IFIH , may predispose individuals to activate innate immune pathways more readily

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reported that Asp and Asn in colon cancer cell lines could inhibit their activities by binding to LKB1 (encoding filament, threonine kinase, and direct phosphorylation of protein products to activate AMPK), thus inhibiting AMPK-mediated p53 activation

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Consequently, chronic alcohol consumption is a major contributor to oxidative stress, which not only promotes ROS production but also disrupts the redox system homeostasis of the body

When combined with liver malignancies, cirrhosis accounts for 3.5% of all deaths worldwide (Asrani et al., 2019)
