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Reduced glutathione (GSH) convert to oxidized glutathione (GSSG) by glutathione peroxidase enzyme that prevents oxidant accumulation

IGF-1R nuclear translocation is closely associated with cell proliferation in multiple breast cancer cell lines and inhibiting IGF-1R nuclear localization reduces cell proliferation and migration in both non-malignant mammary cells and breast carcinoma cells [82,83]
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We therefore initiated treatment with BSO in the drinking water for both male and female -Myc mice at P21 and maintained it until 8 months of age, unless humane endpoints were reached
For example, a significant reduction of hepatic, plasmatic, and lymphocytic GSH levels were noted in patients chronically infected by hepatitis C virus (HCV), particularly with the 1b genotype
