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For example, Staphylococcus epidermidis produces 6-N-hydroxyaminopurine, a molecule that inhibits DNA polymerase activity and selectively suppresses skin tumor proliferation in mice

While certain senolytic compounds have shown specificity for senescent cells in preclinical models, achieving this selectivity in humans remains a significant hurdle.120 For example, some senescence-associated proteins (eg, BCL-2, p53, SASP factors) are also expressed in normal, proliferating cells, leading to potential off-target effects.31 Therefore, optimizing senolytic agents to minimize side effects while maintaining efficacy is crucial

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4.1.5 Polyamines Polyamines are a class of metabolites produced by the intestinal microbiota, primarily comprising putrescine, spermidine, and spermine

Moreover, it has been implied that oxidatively destructed proteins are more susceptible to ubiquitination-facilitated proteasomal degradation [123]

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